Good Article About Source of FM Pain

Fibromyal­gia Pain: Do We Know the Source?

Roland Staud

Pur­pose of review: Fibromyal­gia Syn­drome (FMS) is a chron­ic pain con­di­tion of unknown ori­gin. Mul­ti­ple abnor­mal­i­ties have been described, includ­ing periph­er­al tis­sue and cen­tral ner­vous sys­tem changes. The rela­tion of these mech­a­nisms, how­ev­er, is like­ly bidi­rec­tion­al. FMS pain clear­ly depends on periph­er­al noci­cep­tive input as well as abnor­mal cen­tral pain pro­cess­ing. This review will focus on the role of periph­er­al noci­cep­tive input for pain in FMS.

Recent find­ings: There is strong evi­dence for abnor­mal cen­tral pain pro­cess­ing in FMS. Sen­si­tized spinal cord neu­rons in the dor­sal horn are respon­si­ble for aug­ment­ed pain pro­cess­ing of noci­cep­tive sig­nals from the periph­ery. In addi­tion, glial acti­va­tion, pos­si­bly by cytokines and exci­ta­to­ry amino acids may play a role in the ini­ti­a­tion and per­pet­u­a­tion of this sen­si­tized state.

Sum­ma­ry: Noci­cep­tive input clear­ly plays an impor­tant role in FMS. Acute or repet­i­tive tis­sue injury has been asso­ci­at­ed with FMS pain. Cytokines relat­ed to such injuries may be respon­si­ble for long-term acti­va­tion of spinal cord glia and dor­sal horn neu­rons, thus result­ing in cen­tral sen­si­ti­za­tion. A bet­ter under­stand­ing of these impor­tant neu­ro-immune inter­ac­tions may pro­vide rel­e­vant insights into future effec­tive therapies.

(Med­scape does require reg­is­tra­tion, but it’s free—and a great resource.)

Cyn is Rick's wife, Katie's Mom, and Esther & Oliver's Mémé. She's also a professional geek, avid reader, fledgling coder, enthusiastic gamer (TTRPGs), occasional singer, and devoted stitcher.
Posts created 4255

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Related Posts

Begin typing your search term above and press enter to search. Press ESC to cancel.

Back To Top