Oxygen for CFS?

A research abstract from Dr. Paul Cheney offers an inter­est­ing con­clu­sion.
Oxy­gen Tox­i­c­i­ty as a Locus of Con­trol for Chron­ic Fatigue Syn­drome
“We con­clude that CFS is an oxy­gen tox­ic state and that oxy­gen tox­i­c­i­ty sta­tus appears to deter­mine out­come in ther­a­peu­tic tri­als and is there­fore, a locus of con­trol in chron­ic fatigue syn­drome.”

The pos­si­bil­i­ty of an effi­ca­cious treat­ment for CFS is excit­ing. I’ll be watch­ing the news for more infor­ma­tion on this angle.

Cortisol and FMS and CFS/ME?

There’s been a lot of buzz over the past week about a study pub­lished in the Jour­nal of Chron­ic Fatigue Syn­drome that sug­gests treat­ing fibromyal­gia and ME/CFS with cor­ti­sol (a steroid), based on the fact that most patients have low cor­ti­sol lev­els. I do not have access to that pub­li­ca­tion, but would like to point out some con­cerns.

First, most of the reports are not clear about the fact that this was a lit­er­a­ture study, rather than a con­trolled clin­i­cal study.

Sec­ond, while at least one sto­ry did claim that the lit­er­a­ture study was fol­lowed up with an “obser­va­tion­al study” in which all of the FMS/CFS/ME patients in a par­tic­u­lar clin­ic were giv­en cor­ti­sol. That does not meet the stan­dards of a con­trolled, clin­i­cal study, which would require an untreat­ed con­trol group and a group receiv­ing place­bos instead of cor­ti­sol.

There have been mul­ti­ple clin­i­cal stud­ies of the effects of steroids on FMS/CFS/ME. I found records of stud­ies of pred­nisone and hydro­cor­ti­sone, in par­tic­u­lar. Those stud­ies did not find any pos­i­tive effects from treat­ment com­pared to place­bos, and in some cas­es there were sig­nif­i­cant prob­lems result­ing from the treat­ments. I did not find a study specif­i­cal­ly involv­ing cor­ti­sol, but I don’t know if that’s because there has­n’t been one or because I don’t have access to the appro­pri­ate data­bas­es. (I’m sure there are more stud­ies out there, but I don’t have access to Med­line.)

I’d strong­ly sug­gest wait­ing for the results of repeat­able, con­trolled clin­i­cal tests of cor­ti­sol before try­ing steroid treat­ment. Steroids have seri­ous side effects, and should not be tak­en light­ly.

Brief Update and Review of Witch Way to Murder

I’ve been doing so much read­ing because I’ve been sick and unable to do much else. We did get the girl to her doc­tor, so we know there’s no strep around here. The doc­tor would­n’t rule out mono, but would­n’t test for it either. (I don’t real­ly like this woman, and we usu­al­ly try to go when the nicer physi­cian is there.) She said that since they don’t do any­thing but treat the symp­toms if it is mono, and the con­ta­gion peri­od would have been 60–90 days ago, she does­n’t see any rea­son to run a test.
Con­tin­ue read­ing “Brief Update and Review of Witch Way to Mur­der”