What Was the Name of That Book?

I remem­ber read­ing a book–no, a series–in the ear­ly 90s or so. The clear­est mem­o­ry I have is that there was some sort of drug that made any­one who took it “perfect”–healthy, beau­ti­ful, ath­let­ic, etc. It was also addic­tive after just one dose, and there was no way to get off it–to stop tak­ing it meant death. The main char­ac­ter’s wife was dosed with it so that the sup­pli­ers could con­trol the hero. I think the pro­tag­o­nist was white, and seem to recall that his wife was described as hav­ing an Afro.

Does that trig­ger any mem­o­ries for any­one?